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Phosphorylated Tau 217 antibody (clone PSL263)/50ug (1mg/mL)



Product Datasheet


size 20 to 100 μl
Clone PSL263
form Liquid
Species reactivity human
Isotype Rabbit monoclonal / IgG
Concentration 1mg/ml
Applications WB, ELISA
Storage -20°C, avoid freeze / thaw cycles
Storage buffer PBS, pH 7.4
Expected molecular weight 65-78kD

Product Data

Phospho-Tau217 Antibody in WB

Lane 1: human 1 extracellular vesicle (EV) after ultracentrifugation (100,000 xg)
Lane 2: human 2 extracellular vesicle (EV) after ultracentrifugation (100,000 xg)
Lane 3: human 3 extracellular vesicle (EV) after ultracentrifugation (100,000 xg)
Antibody condition:
1st Ab: anti-phosphorylated tau217 (clone PSL263) at 1/2,000 dilution
2nd Ab: goat anti-rabbit IgG (HRP) at 1/10,000 dilution
Exposure time: 1 second
Diluting buffer: 1% BSA/PBST

Phospho-Tau217 Antibody in ELISA

Antigen coating concentration: 5 μg/ml, 100 μl/well in PBS, pH 7.4, 4°C overnight.
Blocking buffer: 3% skim milk at 37°C for 1 hour.
Antibody condition:
1st Ab: serially diluted anti-phosphorylated tau 217 (clone PSL263) at 37°C for 1 hour
2nd Ab: anti-Rabbit IgG Fc secondary antibody (HRP conjugate) at 1/5,000 dilution in PBST at 37°C for 1 hour

Target Information

Tau protein can be found in neurons, associated with microtubules and predominantly located on axons. Excessive phosphorylation of tau (p-tau) increases the likelihood of intracellular insoluble structures formation, such as neurofibrillary tangles. is increased in Alzheimer's disease (AD), and correlates with clinical progression.1 P-tau217 discriminates AD from other neurodegenerative diseases, with higher accuracy than established MRI-based biomarkers.1 Plasma P-tau217 levels have been shown to increase during the early preclinical stages of AD when insoluble tau aggregates are not yet detectable by tau-PET.2 Importantly, the level of p-tau217 in plasma may hold promise as a biomarker for early AD brain pathology.2

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  1. Palmqvist, S. et. al. JAMA, Vol. 324, Issue 8, Pages 772-781, 2020.
  2. Janelidze, S. et. al. JAMA Neurol, Vol. 78, Issue 2, Pages 149-156, 2021.

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  1. Limited, non-transferable right to use the product solely for internal research purposes. No right to resell the product or any of its contents, either explicitly, implicitly, or through estoppel.
  2. This product, whether partial or as a whole, cannot be used for commercial applications of any kind, including but not limited to quality control and commercial services that involve reporting the results of one's activities for compensation.
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  4. This product is not intended for therapeutic or diagnostic use.


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