EXOSOMES (30-150nm in diameter) are bio-nanoparticles secreted from cells, including disease-specific cells, and make their way into the blood circulation. They contain valuable nucleic acids and proteins from their cells of origin and have proven to contain rich source of clinically relevant diagnostics targets. With a billion exosomes in a millimeter of plasma, exosomes’ diagnostic values are demonstrated in cardiovascular, cancers and a range of life-threatening diseases.