- abundant in blood (109/mL plasma)
- secreted by neurons
- can cross blood-brain barrier (BBB)
- exosomes: 30-150nm diameter
- contain disease-specific cargo
(protein, mRNA, RNA, DNA)
EXOSOMES are bio-nanoparticles from cells, including disease-specific cells, and make their way into the blood circulation. They contain valuable nucleic acids and proteins from their cells of origin and have proven to contain rich source of clinically relevant diagnostics targets.